Roles for dynamic regulation of endothelial cell adhesion

Benjamin Nanes, MD, PhD
Resident Physician
Department of Dermatology
UT Southwestern Medical Center

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Department of Internal Medicine
UT Southwestern Medical Center

MD, 2016

Emory University School of Medicine

Research — Cytoskeletal dynamics in wound healing and re-epithelialization

Advisor: Gaudenz Danuser, PhD (lab website)
  Professor and Chair, Department of Bioinformatics

Non-healing and chronic wounds represent a significant clinical problem, and the development of new therapies has been hampered by our incomplete understanding of the underlying biology. Epidermal keratinocytes resist mechanical stress through molecular scaffolding formed by intermediate filaments. My work in the Danuser lab focuses on the role of intermediate filament composition and organization during re-epithelialization and its contribution to wound healing.

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PhD, 2014 — Dynamic regulation of endothelial cell adhesion

Emory University School of Medicine
Biochemistry, Cell, and Developmental Biology
Advisor: Andrew Kowalczyk, PhD (lab website)
  Professor, Departments of Cell Biology and Dermatology

Endothelial cells, which line the interior surfaces of blood vessels, form a barrier between the intravascular space and the surrounding tissue. These cells must form cell-cell contracts stable enough to prevent uncontrolled vascular leak, but also flexible enough to permit the dynamic rearrangements needed for new vessel formation during development and wound healing. My work has focused on identifying the molecular mechanisms responsible for endothelial junction plasticity and understanding how these pathways are disrupted in diseases characterized by inappropriate loss of endothelial adhesion.

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