Roles for dynamic regulation of endothelial cell adhesion

Benjamin Nanes, MD, PhD
Resident (PGY-1, Medicine-Preliminary; Dermatology)
Department of Internal Medicine
Department of Dermatology
UT Southwestern Medical Center

Research — Dynamic regulation of endothelial cell adhesion

Endothelial cells, which line the interior surfaces of blood vessels, form a barrier between the intravascular space and the surrounding tissue. These cells must form cell-cell contracts stable enough to prevent uncontrolled vascular leak, but also flexible enough to permit the dynamic rearrangements needed for new vessel formation during development and wound healing. My work has focused on identifying the molecular mechanisms responsible for endothelial junction plasticity and understanding how these pathways are disrupted in diseases characterized by inappropriate loss of endothelial adhesion.

PhD, 2014

Emory University School of Medicine
Biochemistry, Cell, and Developmental Biology
Advisor: Andrew Kowalczyk, PhD (lab website)
  Professor, Departments of Cell Biology and Dermatology

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